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Related Concept Videos

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The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
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Transcutaneous Microcirculatory Imaging in Preterm Neonates
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Thyroid Function Test in Preterm Neonates: Normative Data.

Debarghya Mukherjee1, Pradip Mukhopadhyay2, Bijan Saha3

  • 1Department of Pathology, Institute of Post Graduate Medical Education and Research, Kolkata, West Bengal, India.

Indian Journal of Endocrinology and Metabolism
|August 1, 2024
PubMed
Summary

This study establishes crucial thyroid function test reference ranges for preterm neonates (34-35 weeks gestation). These normative values aid in diagnosing hypothyroidism in premature infants during the first month of life.

Keywords:
Preterm neonatesnormative datathyroid function tests

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Area of Science:

  • Neonatal endocrinology
  • Pediatric thyroid function

Background:

  • Thyroid hormones are vital for infant development.
  • Normative data for thyroid function in preterm neonates is limited.
  • Accurate reference ranges are needed for early hypothyroidism diagnosis.

Purpose of the Study:

  • To determine normative values for thyroid function parameters in preterm neonates.
  • To establish reference ranges for T3, T4, FT4, and TSH in premature infants.

Main Methods:

  • Evaluated 102 preterm neonates (34-35 weeks gestation).
  • Measured T3, T4, FT4, and TSH at 3-7 days and 4 weeks postpartum.
  • Used gestational age and Ballard score to confirm gestation.

Main Results:

  • Established mean thyroid hormone levels at 3-7 days and 4 weeks.
  • Observed significant changes in T3, T4, and TSH by 4 weeks, but not FT4.
  • Generated percentile-based normative values for thyroid function tests.

Conclusions:

  • Provided essential normative thyroid function data for preterm neonates (34-35 weeks).
  • These values are valuable for clinical assessment and management of thyroid disorders in premature infants.