RANDOMIZED EXPERIMENTAL STUDY OF TOPICAL VASODILATORS IN MICROSURGERY WITH COST ANALYSIS

Area of Science:

• Vascular Surgery
• Experimental Medicine
• Pharmacology

Background:

• Topical vasodilators are commonly used in microsurgical anastomosis to prevent pathological vasospasm.
• The effectiveness of various agents in reducing vasospasm requires further investigation.

Purpose of the Study:

• To compare the efficacy of topical Nitroglycerin, Papaverine, and Magnesium sulfate in reducing prolonged vasospasm in rat femoral arteries and veins.
• To evaluate Magnesium sulfate as a potential alternative vasodilator in microsurgical procedures.

Main Methods:

• A randomized comparative experimental study was conducted on 15 rats, divided into four groups.
• The external diameter of femoral arteries and veins was measured after topical application of study solutions.
• Percentual increase in vessel diameter was calculated for statistical analysis.

Main Results:

• Topical 10% magnesium sulfate application resulted in a statistically significant increase in arterial dilation after 10 minutes (p = 0.044) compared to the control.
• No other tested drug showed a superior vasodilator effect compared to the control group in arteries.
• No tested drug demonstrated superior vasodilation compared to the control group in veins.

Conclusions:

• Magnesium sulfate at 10% exhibited superior vasodilating effects on arterial microanastomosis compared to the control group.
• None of the tested agents showed superior vasodilation over each other or the control group in venous microanastomosis.
• 10% Magnesium sulfate is a cost-effective alternative to papaverine, with potential applications in microsurgery.