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Surface-Enhanced Raman Scattering Nanosensing and Imaging in Neuroscience
Ryma Boudries1, Hannah Williams1, Soraya Paquereau-Gaboreau1,2,3
1Department of Chemistry, Institut Courtois, Quebec Center for Advanced Materials (QCAM), and Regroupement Québécois sur les Matériaux de Pointe (RQMP), Université de Montréal, C.P. 6128 Succ. Centre-Ville, Montréal, Quebec H3C 3J7, Canada.
ACS Nano
|August 1, 2024
Summary
Surface-enhanced Raman scattering (SERS) nanosensors offer powerful tools for detecting neurochemicals and imaging brain tissues. These advancements are crucial for understanding neurochemistry and brain disorders.
Area of Science:
- Neuroscience
- Biomedical Engineering
- Analytical Chemistry
Background:
- Understanding neurochemistry and brain disorders requires in vitro, ex vivo, and in vivo monitoring of neurochemicals and brain tissue.
- Surface-enhanced Raman scattering (SERS) nanosensors present a promising technology for neurochemical analysis and brain imaging.
Purpose of the Study:
- To review the applications of SERS nanosensors in neuroscience for detecting neurochemicals and imaging brain tissues.
- To highlight recent advancements in SERS nanomaterials, biofluid analysis, and machine learning for spectral interpretation.
- To explore future research directions for SERS in neuroscience, including in vivo monitoring and therapy assessment.
Main Methods:
- Review of existing literature on SERS nanosensors in neuroscience.
- Detailed analysis of studies employing SERS for in vitro, ex vivo, and in vivo neurochemical detection and brain tissue imaging.
- Discussion of advancements in SERS-active nanomaterials and machine learning for spectral data analysis.
Main Results:
- SERS nanosensors can detect clinically relevant levels of neurochemicals in biofluids.
- SERS labeling enables effective imaging of normal and pathological brain tissues, aiding in surgical guidance.
- Recent developments enhance SERS capabilities for in vitro, ex vivo, and in vivo applications.
Conclusions:
- SERS nanosensors hold significant potential for advancing neurochemistry and the study of brain disorders.
- Future applications include enhanced in vivo monitoring and integration with conventional neurochemistry techniques.
- SERS can play a role in evaluating brain disorder therapies and improving surgical outcomes.
