Nanocellulose-alginate composite beads for improving Ciprofloxacin bioavailability

Area of Science:

• Biomaterials Science
• Drug Delivery Systems
• Nanotechnology

Background:

• Nanocellulose's hydrophilic nature and uncontrolled drug release limit its oral drug administration applications.
• Developing effective oral drug delivery systems remains a challenge for enhancing therapeutic efficacy.

Purpose of the Study:

• To develop novel nanocellulose/alginate composite (CNC/Alg) beads for oral delivery.
• To enhance the bioavailability of Ciprofloxacin (CIP) using these composite beads.

Main Methods:

• Green synthesis of nanocellulose (CNC) from sugarcane bagasse via electrolysis.
• Formulation of CNC/Alg beads using a dropwise addition method in CaCl2 solution.
• Incorporation of Ciprofloxacin (CIP) into CNC/Alg beads via adsorption.

Main Results:

• Successfully produced CNC/Alg beads with high crystallinity (75.5%) and characteristic cellulose-alginate bonds.
• Achieved high CIP loading efficiency (45.27%) with adsorption following Elovich and pseudo-second-order models.
• Demonstrated sustained release of CIP (75.05%) in simulated intestinal conditions and protection from acidic stomach environments.
• Exhibited significant antibacterial activity against Gram-negative and Gram-positive bacteria.

Conclusions:

• CNC/Alg composite beads are effective for oral drug delivery.
• The developed beads enhance Ciprofloxacin bioavailability for improved oral administration.
• This approach offers a promising strategy for developing advanced drug delivery systems.