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Association between Pentosan Polysulfate and Subsequent Maculopathy: Insights from a Nationwide Population-Based
Min Seok Kim1, Yong Je Choi2, Eunjeong Ji3
1Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
Purpose:
To determine the association between pentosan polysulfate (PPS) use and the subsequent development of maculopathy in an Asian population.
Design:
A nationwide, population-based retrospective cohort study using the Health Insurance Review and Assessment Service database.
Participants:
A total of 103 553 individuals in the PPS user group and 205 792 individuals in the PPS nonuser group, all newly diagnosed with cystitis between 2009 and 2020.
Methods:
The association between PPS use and maculopathy was evaluated using a time-dependent Cox proportional hazard model. Additionally, 2 sensitivity analyses were conducted by defining PPS users as individuals with an observation period over 6 months from the initial prescription or those with a cumulative dose exceeding 9 g, using the same analysis.
Main Outcome Measures:
The outcome measures included the hazard ratios (HRs) representing the association between PPS use and maculopathy.
Results:
Use of PPS was associated with an increased risk of subsequent maculopathy in univariate (HR, 1.7; 95% confidence interval [CI], 1.66-1.75) and multivariate analysis (HR, 1.34; 95% CI, 1.31-1.38). These results were also confirmed in 2 sensitivity analyses. The mean cumulative dose of PPS for the cohort was 37.2 ± 76.7 g.
Conclusions:
In this nationwide cohort study involving an Asian population, individuals with cystitis using PPS exhibit an increased risk of developing subsequent maculopathy.
Financial Disclosure(S):
The author(s) have no proprietary or commercial interest in any materials discussed in this article.
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