[Sex differences in hepatobiliary and transplantation surgery].

Area of Science:

• Hepatobiliary surgery
• Transplantation surgery
• Oncology

Background:

• Gender-specific differences significantly impact diagnosis, treatment, and outcomes in hepatobiliary and transplantation surgery.
• Men have a higher risk of late recurrences and cancer-specific death post-liver cancer resection.
• Existing disparities in organ transplantation access and drug compatibility require urgent attention.

Purpose of the Study:

• To highlight gender-specific disparities in hepatobiliary and transplantation surgery.
• To emphasize the need for equitable access to treatment and individualized care.
• To underscore the importance of further research for improving patient outcomes.

Main Methods:

• Review of existing literature on gender differences in liver cancer resection.
• Analysis of data on organ transplantation waiting lists and outcomes by gender.
• Examination of gender-specific drug compatibility in transplantation.

Main Results:

• Men show increased risk of late recurrence and cancer-specific death after liver cancer resection.
• Women are underrepresented on kidney and liver transplant waiting lists and face longer waits.
• Gender influences drug compatibility, necessitating differentiated dosing strategies.

Conclusions:

• Addressing gender disparities in screening, treatment access, and drug dosing is vital for hepatobiliary and transplantation surgery.
• Individualized treatment plans considering gender-specific factors can improve patient outcomes and quality of life.
• Further research is essential to achieve equity in transplantation and hepatobiliary care.