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An update on the use of 'biotics' in pediatric infectious gastroenteritis

Alicia Wampers1, Koen Huysentruyt1, Yvan Vandenplas1

  • 1Vrije Universiteit Brussel (VUB), UZ Brussel, KidZ Health Castle, Brussels, Belgium.

Expert Opinion on Pharmacotherapy
|August 2, 2024
PubMed

Insights

Certain probiotics and postbiotics can reduce acute gastroenteritis (AGE) duration and severity by restoring the gut microbiome. More standardized research is needed to confirm efficacy, especially for food supplements.

Area of Science:

  • Microbiology
  • Gastroenterology
  • Nutritional Science

Background:

  • Acute gastroenteritis (AGE) is linked to disruptions in the gastro-intestinal microbiome.
  • Specific probiotic strains, including Lacticaseibacillus rhamnosus and Limosilactobacillus reuteri, have demonstrated efficacy in reducing AGE symptoms.

Purpose of the Study:

  • To review current evidence on probiotics, prebiotics, synbiotics, and postbiotics for managing acute gastroenteritis.
  • To identify limitations in existing research and propose recommendations for future studies.

Main Methods:

  • A literature search was conducted using PubMed and CINAHL databases.
  • Key reviews published up to 2021 were summarized, and new evidence on various 'biotics' in AGE was investigated.

Main Results:

  • Postbiotics show promise due to enhanced product stability and emerging evidence of efficacy.
  • Significant heterogeneity exists in study designs, endpoints, and administration protocols for 'biotics' in AGE, limiting definitive conclusions.

Conclusions:

  • Standardized core outcome sets are needed for pediatric AGE trials to improve evidence homogeneity.
  • The current regulatory landscape for food supplements, prioritizing safety over efficacy, necessitates robust clinical trials (RCTs) before product marketing.
Abstract

Keywords:
Childgastroenteritismicrobiomepostbioticprebioticprobioticsynbiotic

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