Jove
Visualize
Contact Us

Related Concept Videos

Nucleic Acid Structure01:25

Nucleic Acid Structure

6.1K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
6.1K
Next-generation Sequencing03:00

Next-generation Sequencing

88.5K
The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
88.5K
The Replisome03:01

The Replisome

33.3K
DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
The synthesis of the leading and lagging strands is a highly coordinated process. To explain this, the “Trombone model” was proposed by Bruce Alberts in 1980. The DNA loop formation starts when a primer is synthesized on the parent lagging strand. The loop grows with...
33.3K
Nucleic acids02:43

Nucleic acids

161.2K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
161.2K
PCR01:32

PCR

205.4K
Overview
205.4K
Nucleic Acids02:43

Nucleic Acids

44.0K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
44.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Non-enzymatic electrochemical glucose sensing using flexible rGO/AgNW@PANI composite films on nylon substrates.

RSC advances·2026
Same author

Nonequilibrium phases of a biomolecular condensate facilitated by enzyme activity.

Soft matter·2026
Same author

When RNA goes off script: ensuring transcript fidelity in transgene expression.

The EMBO journal·2026
Same author

Sequence-encoded interactions program internal condensate architecture.

bioRxiv : the preprint server for biology·2025
Same author

Current practices in the study of biomolecular condensates: a community comment.

Nature communications·2025
Same author

Sequence-encoded intermolecular base pairing modulates fluidity in DNA and RNA condensates.

Nature communications·2025
Same journal

Genetic Impacts on Variability of Body Fat Distribution Uncover Gene-Environment and Gene-Gene Interactions.

bioRxiv : the preprint server for biology·2026
Same journal

16S ribosomal RNA modification drives transcript-specific translation efficiency.

bioRxiv : the preprint server for biology·2026
Same journal

FlcE latches onto the FliL-stator complex to turbocharge flagellar motility in <i>Borrelia burgdorferi</i>.

bioRxiv : the preprint server for biology·2026
Same journal

Synaptic pruning, myelination and the emergence of psychiatric disorders in late adolescence.

bioRxiv : the preprint server for biology·2026
Same journal

Structural and functional insights into the Rcs phosphorelay.

bioRxiv : the preprint server for biology·2026
Same journal

The structural basis of RanGAP1 regulation and catalysis in nuclear transport.

bioRxiv : the preprint server for biology·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 18, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.2K

Sequence programmable nucleic acid coacervates.

Sumit Majumder1, Sebastian Coupe2, Nikta Fakhri3

  • 1Whitehead Institute for Biomedical Research, Cambridge 02142, USA.

Biorxiv : the Preprint Server for Biology
|August 2, 2024
PubMed
Summary
This summary is machine-generated.

Researchers created programmable DNA and RNA liquids where molecule interactions control material properties. This self-assembly platform offers insights into cellular liquid-like compartments and programmable fluid development.

Keywords:
DNA/RNA nanotechnologyassociative polymersbiomolecular condensatescomplex coacervatesliquid-liquid phase separationprogrammable materials

More Related Videos

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

737
Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.2K

Related Experiment Videos

Last Updated: Jun 18, 2025

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

4.2K
Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures
08:02

Author Spotlight: Developing Synthetic Cells from Programmable Amphiphilic DNA Nanostructures

Published on: May 31, 2024

737
Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.2K

Area of Science:

  • Biomaterials science
  • Molecular biology
  • Soft matter physics

Background:

  • Nature employs self-assembly for complex structures, but linking molecular interactions to macroscopic properties is challenging.
  • Bridging molecular and macroscopic scales requires model systems with tunable properties.

Purpose of the Study:

  • To engineer programmable DNA and RNA liquids with controllable material characteristics.
  • To investigate how molecular hybridization influences the macroscopic properties of these nucleic acid condensates.

Main Methods:

  • Condensation of negatively charged DNA and RNA with polycations to form liquid-like states.
  • Utilizing sequence-specific hybridization to cross-link nucleic acid molecules within the liquid phase.
  • Measuring molecular diffusivity and material viscosity to correlate with hybridization energy.

Main Results:

  • DNA and RNA liquids were successfully generated with programmable material properties.
  • Intermolecular hybridization was shown to cross-link molecules, reduce chain dynamics, and slow molecular diffusion.
  • Macroscopic properties like viscosity and diffusivity were precisely modulated by controlling hybridization energy through sequence design.

Conclusions:

  • Nucleic acid liquids provide a robust platform for creating self-assembling programmable fluids.
  • The study demonstrates sequence-based control over material properties, bridging molecular interactions and macroscopic behavior.
  • This work may enhance understanding of intracellular liquid-like compartments and inform the design of novel biomaterials.