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Updated: Jun 18, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
09:08

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer

Published on: January 12, 2020

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Targeting Notch signaling pathways with natural bioactive compounds: a promising approach against cancer

Jia Yang1,2,3, Qihui Sun1,4, Xiaoyun Liu5

  • 1College of Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China.

Frontiers in Pharmacology
|August 2, 2024
PubMed

Insights

Natural compounds can inhibit the Notch signaling pathway, a key factor in tumor growth and cancer progression. Targeting this pathway offers new therapeutic strategies for cancer treatment.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Notch signaling pathway is crucial for cell functions and is abnormally activated in various cancers.
  • Notch pathway activation and its crosstalk with other oncogenic pathways increase cancer aggressiveness.
  • Targeting Notch signaling presents a promising strategy for cancer therapy.

Purpose of the Study:

  • To review natural bioactive compounds that inhibit the Notch pathway in human cancers.
  • To explore the potential of these compounds in preventing Notch crosstalk with other oncogenic pathways.
  • To highlight Notch as a therapeutic target for novel anticancer drug development.

Main Methods:

  • Literature review of studies on natural bioactive compounds and Notch signaling in cancer.
  • Analysis of mechanisms by which natural compounds impede Notch pathway activation.
  • Examination of the role of Notch pathway crosstalk in cancer progression.

Main Results:

  • Several natural bioactive compounds demonstrate inhibitory effects on Notch signaling in cancer cells.
  • These compounds can prevent Notch crosstalk with other oncogenic pathways, reducing cancer aggressiveness.
  • Natural products offer a viable source for developing new cancer therapeutics.

Conclusions:

  • Natural bioactive compounds show significant potential in targeting the Notch pathway for cancer treatment.
  • Further research into these compounds could lead to novel therapeutic regimens and anticancer drugs.
  • The Notch pathway is a challenging yet highly promising target in oncology.
Keywords:
cancercrosstalknotch signalingoncogenic pathwaysphytochemicals

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