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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Role of Vitamins in Maintaining Bone Health01:25

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The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
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Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Updated: Jun 18, 2025

Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice
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Author Spotlight: Integrating Traditional Chinese Medicine with Modern Pharmacology and Genomics for Assessing Postmenopausal Osteoporosis in Mice

Published on: August 23, 2024

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Correlation study: Bone density and circulating inflammatory markers in postmenopausal patients.

Xingyu Jin1, Ye Wang1, Huazheng Wang1

  • 1Department of Orthopedics, Suzhou BenQ Medical Center, The Affiliated BenQ Hospital of Nanjing Medical University, Suzhou, China.

Immunity, Inflammation and Disease
|August 2, 2024
PubMed
Summary
This summary is machine-generated.

Inflammatory markers like white blood cell count and the systemic immune-inflammation index show predictive value for postmenopausal osteoporosis (PMOP). Routine blood tests can help assess this bone condition in women.

Keywords:
blood routineinflammatory indexpostmenopausal osteoporosissystemic immune‐inflammation index

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Area of Science:

  • Endocrinology and Bone Metabolism
  • Immunology and Inflammation
  • Geriatric Medicine

Background:

  • Postmenopausal osteoporosis (PMOP) is a significant health concern in aging women.
  • Inflammation is increasingly recognized as a contributing factor to bone density loss.
  • Identifying reliable markers for early detection and prediction of PMOP is crucial.

Purpose of the Study:

  • To investigate the correlation between changes in bone mineral density (BMD) in postmenopausal women and circulating inflammatory markers.
  • To assess the predictive value of specific inflammatory markers and the systemic immune-inflammation index (SII) for PMOP.

Main Methods:

  • Retrospective study of postmenopausal women admitted to Suzhou Benq Medical Center (June 2022 - December 2023).
  • Collected data on bone density measurements and routine blood tests, including white blood cell count (WBC), C-reactive protein, interleukin-6 (IL-6), and procalcitonin (PCT).
  • Calculated the systemic immune-inflammation index (SII) and performed statistical analyses (Principal Component Analysis, Correlation Analysis, ANOVA, ROC curve).

Main Results:

  • Principal Component Analysis identified WBC, SII, and PMOP as significant features.
  • Correlation analysis revealed significant associations between WBC, IL-6, SII, and PMOP.
  • ANOVA showed significant differences in IL-6, SII, and PCT among osteoporosis, osteopenia, and normal BMD groups. ROC analysis indicated SII has predictive value for PMOP (AUC=0.716).

Conclusions:

  • Circulating inflammatory markers, particularly WBC and SII, are correlated with reduced BMD in postmenopausal women.
  • The systemic immune-inflammation index (SII) demonstrates predictive value for postmenopausal osteoporosis.
  • Routine blood tests assessing inflammatory markers offer a potential tool for evaluating PMOP risk.