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The effectiveness of early systemic inflammatory indices in predicting advanced intraventricular hemorrhage in
Ufuk Cakir1, Cuneyt Tayman1, Ali Ulas Tugcu1
1Health Science University, Ankara, Turkey.
Insights
Systemic inflammatory indices do not predict severe intraventricular hemorrhage (IVH) in premature infants. This study found no significant differences in these markers between infants with and without severe IVH, suggesting they are not useful for early detection.
Area of Science:
- Neonatal Medicine
- Pediatric Critical Care
- Inflammation Research
Background:
- Systemic inflammatory indices are linked to intracerebral hemorrhage in adults.
- The association between these indices and intraventricular hemorrhage (IVH) in premature neonates remains unclear.
Purpose of the Study:
- To investigate the predictive value of systemic inflammatory indices on the first day of life for severe IVH in premature infants.
- To determine if markers like NLR, MLR, PLR, SII, PIV, and SIRI can identify neonates at risk for severe IVH.
Main Methods:
- A cohort of premature infants (< 32 weeks gestational age) was analyzed.
- Infants were categorized into groups based on IVH severity (grades I-II vs. grades III-IV).
- Demographic data and various systemic inflammatory indices (NLR, MLR, PLR, SII, PIV, SIRI) were compared between groups.
Main Results:
- No significant differences were observed in leukocyte, neutrophil, monocyte, lymphocyte, or platelet counts between the groups.
- Key inflammatory indices, including NLR, MLR, PLR, PIV, SII, and SIRI, showed no significant variation between infants with and without severe IVH.
- The study included 1176 newborns, with 1074 in the lower IVH grade group and 102 in the severe IVH group.
Conclusions:
- Systemic inflammatory indices, including NLR, MLR, PLR, SII, PIV, and SIRI, do not appear to have predictive value for the development of severe IVH in premature neonates.
- Further research is needed to understand the complex interplay between inflammation, hemodynamics, and IVH in this vulnerable population.
Abstract:
Some systemic inflammatory indices have been reported to be associated with intracerebral hemorrhage in adults. However, the relationship between systemic inflammatory indices and intraventricular hemorrhage (IVH) in premature neonates is still not completely understood.
Objective:
To evaluate the relationship between systemic inflammatory indices obtained on the first day of life in premature infants and the development of severe IVH.
Patients And Method:
Premature newborns < 32 weeks of gestational age were included. Eligible patients were divided into 2 groups: Group 1: without IVH or grade I and II hemorrhage, and Group 2: grade III and IV HIV. Demographic characteristics, clinical outcomes, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune inflammation index (SII), pan-immune inflammation value (PIV), and Systemic inflammation response index (SIRI) were compared between groups.
Results:
A total of 1176 newborns were included in the study, 1074 in Group 1 and 102 premature babies in Group 2. There was no difference between the groups in terms of the count of leukocytes, neutrophils, monocytes, lymphocytes and platelets (p > 0.05). The values of NLR, MLR, PLR, PIV, SII and SIRI were similar in both groups (p > 0.05).
Conclusion:
While the relationship between inflammation, hemodynamics and IVH is still under discussion, our results show that systemic inflammatory indices have no predictive value for IVH.
