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Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
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Endoplasmic Reticulum Stress Promotes Telomerase Reverse Transcriptase Expression Contributes to Development of
Yun Liao1, Xiwen Zhang1,2, Shuang Tao1,2
1Department of Otolaryngology, Longgang Central Hospital affiliated to Shenzhen Clinical College, Guangzhou University of Chinese Traditional Medicine, Shenzhen, China.
American Journal of Rhinology & Allergy
|August 2, 2024
Summary
Telomerase promotes Th2 cell polarization in allergic rhinitis (AR) by degrading Foxp3. Inhibiting telomerase reverse transcriptase (TERT) or eIF2a alleviates AR in mice, suggesting therapeutic potential.
Area of Science:
- Immunology
- Molecular Biology
- Allergy Research
Background:
- Th2 cell polarization is central to allergic disease pathogenesis.
- Telomerase possesses immune-regulatory functions requiring further investigation.
- The link between telomerase and Th2 polarization in allergic rhinitis (AR) is unclear.
Purpose of the Study:
- To investigate the association between telomerase and Th2 cell polarization in AR patients.
- To elucidate the role of telomerase reverse transcriptase (TERT) in AR pathogenesis.
Main Methods:
- CD4+ T cells isolated from AR patients and healthy controls.
- RNA sequencing performed on CD4+ T cells.
- An AR mouse model induced via ovalbumin-alum sensitization.
Main Results:
- Elevated telomerase activity and ER stress in AR CD4+ T cells.
- TERT expression positively correlated with AR severity.
- TERT degrades Foxp3, promoting Th2 polarization; ER stress enhances Tert expression.
- Inhibiting Tert or Eif2a reduced experimental AR in mice.
Conclusions:
- Telomerase is elevated in AR CD4+ T cells and drives Th2 polarization via Foxp3 degradation and GATA3 activation.
- TERT and eIF2a inhibition show therapeutic potential for AR.
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