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Updated: Aug 12, 2026

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Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
Published on: December 17, 2019
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Macrophages: A missing key in cardiac tissue engineering for sustained vascularization
Christian J Mandrycky1, Ying Zheng1
1Department of Bioengineering, Institute of Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA.
Cell Stem Cell
|August 2, 2024
Abstract
None:
Macrophages regulate angiogenesis, repair, conduction, and homeostasis in heart tissue. Landau et al.1 demonstrate that incorporating primitive macrophages into engineered heart tissues significantly promotes long-term vascularization and cardiac maturation. This advance demonstrates the importance of resident immune-vascular microenvironments in cardiac tissue engineering, marking an important step forward for heart-on-chip technologies.

