[Peroxisomes--in search of their function in man]

Area of Science:

• Cell Biology
• Biochemistry
• Genetics

Context:

• Peroxisomes are single-membrane bound organelles found in eukaryotic cells.
• Their structure includes a unique triple-layered membrane.
• Peroxisomes host a growing list of essential enzymes.

Purpose:

• To review the current understanding of peroxisomal functions.
• To highlight the enzymes localized within peroxisomes.
• To discuss the implications of peroxisomal dysfunction.

Summary:

• Significant advancements have been made in understanding fatty acid beta-oxidation and glycerolipid biosynthesis within peroxisomes.
• Aberrations in peroxisomal function are associated with specific genetic disorders, including Zellweger syndrome and adrenoleukodystrophy.
• Further peroxisomal disorders are anticipated to be identified.

Impact:

• Increased knowledge of peroxisomal enzymes and metabolic pathways.
• Improved diagnosis and understanding of inherited peroxisomal diseases.
• Potential for future therapeutic targets for peroxisomal disorders.