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Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

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Related Experiment Video

Updated: May 5, 2026

Counting Proteins in Single Cells with Addressable Droplet Microarrays

Counting Proteins in Single Cells with Addressable Droplet Microarrays

Published on: July 6, 2018

Concepts and new developments in droplet-based single cell multi-omics.

Arthur Chow¹, Caleb A Lareau¹

¹Computational and Systems Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Trends in Biotechnology

|August 2, 2024

Summary

This summary is machine-generated.

Single cell sequencing using droplet microfluidics offers powerful cell analysis. Recent innovations enhance the reliability and understanding of these complex single-cell multi-omics assays.

Keywords:

bioinformatics microfluidics multi-omics sequencing single cell

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Last Updated: May 5, 2026

Counting Proteins in Single Cells with Addressable Droplet Microarrays

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Published on: July 6, 2018

An Ultrahigh-throughput Microfluidic Platform for Single-cell Genome Sequencing

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Automated and High-throughput Microbial Monoclonal Cultivation and Picking Using the Single-cell Microliter-droplet Culture Omics System

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Published on: March 14, 2025

Area of Science:

Molecular biology
Genomics
Biotechnology

Background:

Single cell sequencing is crucial for molecular profiling, offering ease, flexibility, and commercial availability.
Microfluidic droplet technology enables parallel transcriptomic and multi-omic measurements for thousands of cells.
Advancements in assay baselines have deepened the understanding of complex single-cell multi-omics data.

Purpose of the Study:

To highlight four key innovations improving droplet microfluidic assays.
To provide guidelines for developing, benchmarking, and implementing new droplet-based methods.
To enhance the reliability and comprehension of single-cell multi-omics data.

Main Methods:

Review of recent innovations in droplet microfluidic technologies.
Analysis of advancements in assay baselines for single-cell multi-omics.
Emphasis on principles for technology development and implementation.

Main Results:

Four innovations have significantly improved the reliability of droplet microfluidic assays.
New developments offer enhanced understanding of complex single-cell multi-omics data.
Established guidelines for designing and benchmarking new droplet-based methodologies.

Conclusions:

Innovations in droplet microfluidics are critical for advancing single-cell multi-omics.
Reliability and understanding of these assays are improved through technological advancements.
Standardized design and implementation principles are essential for future droplet-based methodologies.