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Protocol for establishing spontaneous metastasis in mice using a subcutaneous tumor model
Shiqin Liu1, Michelle Shen1, Kewei Le1
1Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
STAR Protocols
|August 3, 2024
Summary
This study details a mouse model protocol for spontaneous cancer metastasis. It enables researchers to study cancer progression and test new therapies in vivo.
Area of Science:
- Oncology
- Cancer Research
- Preclinical Models
Background:
- Spontaneous metastasis recapitulation is vital for cancer research.
- Understanding cancer progression and therapeutic interventions requires accurate preclinical models.
Purpose of the Study:
- To present a protocol for establishing and characterizing a spontaneous metastasis model in mice.
- To provide a tool for studying metastasis in vivo and evaluating therapeutic strategies.
Main Methods:
- Generating primary tumors.
- Performing tumor resection.
- Monitoring metastatic dissemination.
- Evaluating metastatic burden using histological and imaging techniques.
Main Results:
- The protocol allows for the establishment and characterization of spontaneous metastasis in mice.
- It facilitates the study of cancer progression and metastasis in a preclinical setting.
Conclusions:
- This protocol is a valuable tool for cancer metastasis research.
- It aids in testing therapeutic strategies for preventing or targeting metastatic diseases.
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