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Simple flow cytometry method using a myeloma panel that easily reveals clonal proliferation of mature B-cells

Mika Araki1, Takayuki Mitsuhashi2, Yoko Yatabe1

  • 1Clinical Laboratory, Keio University Hospital, Tokyo, Japan.

Clinical Chemistry and Laboratory Medicine
|August 4, 2024
PubMed
Abstract

No abstract available in PubMed .

Keywords:
cytoplasmic immunoglobulin light chainflow cytometrygatingmature B-cell lymphomaplasma cell myelomaplasmacytic differentiation

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The development of flow cytometry techniques began in 1934 with initial attempts by Andrew Moldavan, a bacteriologist who counted the cells in a flowing capillary system. Moldavan pumped cells through a capillary tube focused under a microscope for visualization. The invention of photometry allowed the measurement of differentially-stained cells, and Louis Kamentsky developed the first multiparameter flow cytometer in 1965 to identify and count the cancer cells in cervical tissue specimens.
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