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Using real-world data to accelerate the search for long COVID therapies
Shira R Strongin1, Elisabeth Stelson2, Letícia Soares3
1Critical Path Institute, United States of America.
Life Sciences
|August 4, 2024
Summary
Long COVID treatments are urgently needed. This research proposes parallel studies of disease mechanisms and therapies, using patient data to test existing FDA-approved drugs in adaptive trials.
Area of Science:
- Infectious Diseases
- Clinical Therapeutics
- Public Health
Background:
- Long COVID, a post-SARS-COV-2 condition, presents diverse symptoms impacting quality of life.
- Current treatments for Long COVID are lacking, necessitating urgent therapeutic research.
- Research into Long COVID pathophysiology is advancing, but treatment investigations are underfunded.
Purpose of the Study:
- To propose a novel, parallel approach to Long COVID research.
- To accelerate the discovery and confirmation of effective Long COVID therapeutics.
- To leverage patient-centered research and real-world data for hypothesis generation.
Main Methods:
- Parallel investigation of Long COVID pathophysiology and therapeutic strategies.
- Utilizing patient-centered research and real-world data to identify potential treatments.
- Employing adaptive platform clinical trials for efficient and cost-effective drug evaluation.
- Assessing the effectiveness of existing FDA-approved drugs for Long COVID.
Main Results:
- (Study not yet conducted - proposal stage)
- (Study not yet conducted - proposal stage)
- (Study not yet conducted - proposal stage)
Conclusions:
- A parallel research approach integrating pathophysiology and therapeutics is proposed for Long COVID.
- Leveraging real-world data and adaptive trials can expedite the identification of effective treatments.
- This strategy aims to address the urgent need for Long COVID therapies.
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