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Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

Overview
Plant Breeding and Biotechnology01:59

Plant Breeding and Biotechnology

Crop cultivation has a long history in human civilization, with records showing the cultivation of cereal plants beginning at around 8000 BC. This early plant breeding was developed primarily to provide a steady supply of food.
Transgenic Plants02:50

Transgenic Plants

Recombinant DNA technology called transgenesis is often used to add a foreign gene or remove a detrimental gene from an organism. Such genetically modified organisms are called transgenic organisms.
The first-ever transgenic plant was a tobacco plant developed in 1983 that showed resistance against the tobacco mosaic virus. Since then, many transgenic plants have been developed and commercialized for improving the agricultural, ornamental, and horticultural value of a crop plant. Transgenic...

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Assessment of genetically modified maize MON 95275 (application GMFF-2022-5890).

, Ewen Mullins, Jean-Louis Bresson

    EFSA Journal. European Food Safety Authority
    |August 5, 2024
    PubMed
    Summary

    Genetically modified maize MON 95275, engineered for coleopteran pest protection, shows no safety concerns for human or animal consumption. Environmental risk assessments confirm it is as safe as conventional maize varieties.

    Keywords:
    DvSnf7GMMON 95275Mpp75Aa1.1Vpb4Da2genetic engineeringimport and processingmaize (Zea mays)

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    Area of Science:

    • Agricultural Science
    • Genetics
    • Toxicology

    Background:

    • Genetically modified maize MON 95275 was developed to provide protection against specific coleopteran species.
    • The genetic modification involved introducing expression cassettes for mpp75Aa1.1, vpb4Da2, and DvSnf7.

    Purpose of the Study:

    • To assess the safety of genetically modified maize MON 95275 for human and animal consumption and the environment.
    • To evaluate potential toxicity, allergenicity, and nutritional aspects compared to conventional maize.

    Main Methods:

    • Molecular characterization and bioinformatic analyses of introduced genes and proteins.
    • Comparative assessment of agronomic, phenotypic, and compositional characteristics.
    • Evaluation of toxicity and allergenicity of expressed proteins and RNA molecules.
    • Risk assessment for human, animal, and environmental health.

    Main Results:

    • Molecular analyses revealed similarities to known toxins, with no significant safety concerns identified.
    • No significant differences in agronomic, phenotypic, or compositional characteristics were found compared to conventional counterparts.
    • The GMO Panel found no toxicity or allergenicity concerns for Mpp75Aa1.1, Vpb4Da2, DvSnf7 dsRNA, and derived siRNAs.
    • Consumption of food and feed from MON 95275 poses no nutritional concern for humans and animals.
    • Accidental environmental release of MON 95275 is not expected to raise environmental safety concerns.

    Conclusions:

    • Genetically modified maize MON 95275 is as safe as conventional maize varieties for consumption and poses no environmental risks.
    • No post-market monitoring for food/feed or the environment is deemed necessary.
    • The genetic modification does not alter the overall allergenicity of the maize.