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Wnt/beta-catenin modulation: A promising frontier in chronic kidney disease management

Shubhangi Saxena1, Neha Dagar1, Vishwadeep Shelke1

  • 1Department of Pharmacy, Birla Institute of Technology and Science-Pilani, Pilani Campus, Pilani, Rajasthan, India.

Fundamental & Clinical Pharmacology
|August 5, 2024
PubMed
Abstract

Insights

Targeting the Wnt/β-catenin pathway shows promise for managing chronic kidney disease (CKD). Modulating this conserved signaling pathway offers effective therapeutic strategies for alleviating CKD progression.

Area of Science:

  • Nephrology
  • Molecular Biology
  • Pharmacology

Background:

  • Chronic kidney disease (CKD) affects 850 million globally, posing significant health challenges.
  • The Wnt/β-catenin signaling pathway is crucial for kidney homeostasis and is dysregulated in CKD.
  • β-catenin expression increases in adult kidneys under stress, making it a potential therapeutic target.

Purpose of the Study:

  • To review the significance of targeting the Wnt/β-catenin signaling pathway for CKD management.
  • To highlight the role of Wnt/β-catenin modulation in alleviating CKD.

Main Methods:

  • Comprehensive literature review using PubMed, Scopus, Science Direct, and Google Scholar.
  • Focused on studies investigating Wnt/β-catenin signaling in CKD and related therapeutic interventions.

Main Results:

  • Summarizes pharmacological therapies that modulate the Wnt/β-catenin axis in CKD.
  • Highlights promising preclinical findings that support future clinical investigations.

Conclusions:

  • Wnt/β-catenin signaling is a highly conserved pathway critical to CKD progression.
  • Therapies targeting Wnt/β-catenin signaling represent effective strategies for CKD treatment.
Keywords:
Wnt/β‐catenin signallingcanonical Wnt/β‐catenin pathwaychronic kidney diseasenon‐canonical Wnt/β‐catenin pathwaytargeted therapies

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