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Structure-function coupling in macroscale human brain networks.
Panagiotis Fotiadis1,2,3, Linden Parkes4, Kathryn A Davis5
1Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. pfotiad@med.umich.edu.
Nature Reviews. Neuroscience
|August 5, 2024
Summary
Structure-function coupling (SFC) links brain anatomy to brain activity, offering deeper insights than either alone. Aberrant SFC is linked to neurological and psychiatric conditions, showing potential as a disease biomarker.
Area of Science:
- Neuroscience
- Brain Connectivity
- Systems Neuroscience
Background:
- The precise relationship between brain's anatomical structure and its complex functions is not fully understood.
- Brain region activity often depends on the underlying white matter architecture, a key aspect of structure-function coupling (SFC).
Purpose of the Study:
- To review literature on macroscale structure-function coupling (SFC) in the human brain.
- To establish SFC as a valuable tool for understanding brain mechanisms and neurological/psychiatric conditions.
Main Methods:
- Literature review of studies examining macroscale SFC.
- Definition and quantification of SFC using computational methods.
- Analysis of empirical studies on SFC variations across regions, individuals, tasks, and time.
Main Results:
- SFC provides more comprehensive information about brain function than structural or functional connectivity alone.
- SFC varies heterogeneously across brain regions, individuals, cognitive tasks, and over time.
- Aberrant SFC is associated with neurological and psychiatric conditions, correlating with disease duration and cognitive deficits.
Conclusions:
- SFC is crucial for flexible cognition and understanding brain dynamics.
- Altered SFC in disease states offers insights into etiology and potential as a sensitive biomarker for symptomatology and cognitive performance.
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