Copper-catalyzed aerobic annulation of hydrazones with dienones: an efficient route to pyrazole-linked hybrid
Kalinga H Nayak1, Robert K Jijin1, Mariswamy K Sreelekha1
1Department of Chemistry, National Institute of Technology Karnataka, Surathkal, Mangalore, 575025, India. pbbeneesh@nitk.edu.in.
Abstract:
A copper-catalyzed aerobic [3 + 2] annulation reaction to access various pyrazole-bound chalcones starting from readily available and cost-effective hydrazones and dienones is reported. These pyrazole-bound chalcones were further utilized effectively to prepare a series of pyrazole-linked hybrid molecules, such as pyrazole-pyrazoline, pyrazole-aziridine, and pyrazole-pyridine hybrids by efficient simple transformations. Synthetically challenging hybrid molecules were obtained in a simple, two-step process with high atom economy under aerobic copper catalysis.
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