Related Experiment Video

Updated: Jun 17, 2025

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
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Published on: March 27, 2020

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The role of DAPK2 as a key regulatory element in various human cancers: a systematic review

Mohammadreza Saberiyan1, Mahboobeh Zarei2, Amir Safi3

  • 1Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.

Molecular Biology Reports
|August 6, 2024
PubMed

Insights

Death-associated kinase 2 (DAPK2) functions as a tumor suppressor by initiating apoptosis and autophagy. Its interactions suggest DAPK2 is a potential therapeutic target for cancers like gastric, ovarian, and breast cancer.

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Oncology

Background:

  • Cancer involves uncontrolled cell growth, influenced by molecular factors like the death-associated kinase (DAPK) family.
  • DAPK2, a member of the DAPK family, plays crucial roles in cellular processes and acts as a tumor suppressor.

Purpose of the Study:

  • To review the role of DAPK2 in cancer, focusing on its mechanisms in apoptosis and autophagy.
  • To evaluate DAPK2 as a potential therapeutic target in various human cancers.

Main Methods:

  • Literature review of studies from Scopus, PubMed, and Web of Science.
  • Analysis of DAPK2's interactions with key proteins and signaling pathways.

Main Results:

  • DAPK2 activates autophagy through interactions with AMPK, mTORC1, and p73.
  • DAPK2 induces apoptosis via interactions with the p73 family and JNK.
  • DAPK2 expression leads to cellular structural changes and apoptosis.

Conclusions:

  • DAPK2 is vital in cell physiology, regulating apoptosis and autophagy.
  • DAPK2's multifaceted role makes it a promising therapeutic target for gastric, ovarian, breast, and other cancers.
Keywords:
ApoptosisAutophagyCancer targeted therapyCell deathDAPK2Signaling pathways

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