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Updated: Jun 17, 2025
07:37
Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
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One Year Changes in Body Composition and Musculoskeletal Health Following Metabolic/Bariatric Surgery
Friedrich C Jassil1,2,3, Maria Papageorgiou4,5, Emily Mackay1
1Centre for Obesity Research, University College London, London WC1E 6JF, UK.
The Journal of Clinical Endocrinology and Metabolism
|August 7, 2024
Summary
One-anastomosis gastric bypass (OAGB), Roux-en-Y gastric bypass (RYGB), and sleeve gastrectomy (SG) offer comparable weight loss and body composition changes. However, OAGB and RYGB showed greater bone mineral density reductions than SG.
Area of Science:
- Bariatric Surgery
- Metabolic and Endocrine Surgery
- Body Composition Analysis
- Musculoskeletal Health
Background:
- Limited comparative data exists for one-anastomosis gastric bypass (OAGB) versus Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG).
- Impact on body composition and musculoskeletal health requires further investigation.
Purpose of the Study:
- To compare body composition, bone mineral density (BMD), muscle strength, and physical function changes within one year post-OAGB, RYGB, and SG.
- Evaluate outcomes in a UK healthcare setting.
Main Methods:
- Secondary analysis of the BARI-LIFESTYLE trial involving 119 adults undergoing OAGB, RYGB, or SG.
- Assessed body composition, areal BMD (aBMD), handgrip strength, sit-to-stand (STS) test, and 6-minute walking test (6MWT) pre- and post-surgery (12 months).
Main Results:
- All surgical procedures led to significant reductions in body weight, fat mass, and lean mass.
- aBMD decreased at the total hip, femoral neck, and lumbar spine for all groups, with greater reductions after OAGB and RYGB compared to SG.
- Relative muscle strength and physical function (STS, 6MWT) improved across all procedures, with no significant differences between surgical types.
Conclusions:
- OAGB, RYGB, and SG achieve similar weight loss, body composition changes, and improvements in relative strength and physical function.
- OAGB and RYGB are associated with more pronounced reductions in BMD at key skeletal sites compared to SG.
- Further long-term research is needed to determine if BMD changes impact fracture risk.
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