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Antibiotic Nanoparticles-Loaded Wound Dressings Against Pseudomonas aeruginosa's Skin Infection: A Systematic Review
María I Quiñones-Vico1,2,3,4, Ana Ubago-Rodríguez1,2,3, Ana Fernández-González1,2,3
1Cell Production and Tissue Engineering Unit, Virgen de las Nieves University Hospital, Granada, 18014, Spain.
Insights
Novel wound dressings combining nanoparticles (NPs) with antibiotics show promise for treating Pseudomonas aeruginosa infections. However, clinical trials are needed to confirm the safety and efficacy of these advanced antibiotic nanoparticle wound dressings.
Area of Science:
- Biomedical Engineering
- Materials Science
- Infectious Diseases
Background:
- Pseudomonas aeruginosa is a multidrug-resistant nosocomial pathogen causing severe infections.
- Conventional antibiotic treatments for wound infections have limitations including toxicity and resistance.
- Nanoparticle-loaded wound dressings offer a promising strategy to enhance antibiotic safety and efficacy.
Purpose of the Study:
- To review and analyze the latest research on wound dressings loaded with antibiotic nanoparticles.
- To evaluate the properties, antimicrobial activity, and biocompatibility of various nanoparticle-based wound dressing strategies.
- To identify research gaps and future directions for clinical translation.
Main Methods:
- Systematic literature search for studies on antibiotic nanoparticle-loaded wound dressings.
- Analysis of nanoparticle properties, wound dressing characteristics, and antimicrobial efficacy.
- Assessment of biocompatibility and safety data from evaluated studies.
Main Results:
- Most research focuses on silver nanoparticles (57.1%) and other inorganic nanoparticles (22.4%).
- Polymeric nanoparticles (14.3%) and carbon-based nanoparticles (6.1%) are also explored.
- No clinical trials have yet evaluated the efficacy of these nanoparticle-loaded wound dressings in patients.
Conclusions:
- Nanoparticle-loaded wound dressings represent an innovative approach for managing Pseudomonas aeruginosa infections.
- Further research is essential to ensure treatment safety and facilitate clinical application.
- Bridging the gap between laboratory findings and patient bedside is crucial for therapeutic advancement.
Abstract:
Pseudomonas aeruginosa (P. aeruginosa) is a common nosocomial pathogen that can cause severe infections in critically ill patients. Due to its resistance to multiple drugs, it is challenging to treat, which can result in serious illness and death. Conventional treatments for infected wounds often involve the topical or systemic application of antibiotics, which can lead to systemic toxicity and the development of drug resistance. The combination of wound dressings that promote wound healing with nanoparticles (NPs) represents a revolutionary strategy for optimizing the safety and efficacy of antibiotics. This review assesses a systematic search to identify the latest approaches where the evaluation of wound dressings loaded with antibiotic NPs is conducted. The properties of NPs, the features of wound dressings, the antimicrobial activity and biocompatibility of the different strategies are analyzed. The results indicate that most research in this field is focused on dressings loaded with silver NPs (57.1%) or other inorganic materials (22.4%). Wound dressings loaded with polymeric NPs and carbon-based NPs represent 14.3% and 6.1% of the evaluated studies, respectively. Nevertheless, there are no clinical trials that have evaluated the efficacy of NPs-loaded wound dressings in patients. Further research is required to ensure the safety of these treatments and to translate the findings from the bench to the bedside.
