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Updated: Jun 17, 2025
Improving High Viscosity Extrusion of Microcrystals for Time-resolved Serial Femtosecond Crystallography at X-ray Lasers
Published on: February 28, 2019
On the feasibility of time-resolved X-ray powder diffraction of macromolecules using laser-driven ultrafast X-ray
Krishna Prasad Khakurel1, Gabriel Žoldák2, Borislav Angelov1
1Extreme Light Infrastructure ERIC, Za Radnici 835, 25241Dolni Brezany, Czechia.
Abstract:
With the emergence of ultrafast X-ray sources, interest in following fast processes in small molecules and macromolecules has increased. Most of the current research into ultrafast structural dynamics of macromolecules uses X-ray free-electron lasers. In parallel, small-scale laboratory-based laser-driven ultrafast X-ray sources are emerging. Continuous development of these sources is underway, and as a result many exciting applications are being reported. However, because of their low flux, such sources are not commonly used to study the structural dynamics of macromolecules. This article examines the feasibility of time-resolved powder diffraction of macromolecular microcrystals using a laboratory-scale laser-driven ultrafast X-ray source.
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