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Related Concept Videos

G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

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GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
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Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

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Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several...
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Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

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Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
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Regulation of Pulse01:20

Regulation of Pulse

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Pulse regulation involves physiological mechanisms that ensure adequate blood flow throughout the body. The heartbeat, regulated by the autonomic nervous system, is influenced by hormonal balance, physical activity, and emotional state.
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Cardiac Action Potential01:30

Cardiac Action Potential

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Cardiac action potentials are essential for proper heart function, enabling the rhythmic contractions needed for adequate blood circulation. Nodal cells and Purkinje fibers, specialized for electrical conduction, generate these action potentials.
The cardiac action potential process involves a series of phases characterized by the movement of ions across the cardiac cell membranes, leading to the depolarization and repolarization of the cardiac myocytes.
Ionic Basis of Cardiac Action Potentials
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Regulation of Heart Rates01:31

Regulation of Heart Rates

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The regulation of heart rate is a complex process controlled by the autonomic nervous system (ANS), hormonal influences, and intrinsic cardiac mechanisms. The ANS has two main components: the sympathetic nervous system (SNS) and the parasympathetic nervous system (PNS).
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Related Experiment Video

Updated: Jun 17, 2025

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques
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Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques

Published on: September 27, 2011

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Kv1.1 channels help set the pace.

Ben Short1

  • 1Science Writer, Rockefeller University Press , New York, NY, USA.

The Journal of General Physiology
|August 7, 2024
PubMed
Summary

Potassium voltage-gated channel subfamily A member 1 (Kv1.1) channels, despite low levels and small currents, significantly impact cardiac pacemaking in the sinoatrial node. This finding is crucial for understanding heart rhythm regulation.

Area of Science:

  • Cardiovascular Physiology
  • Ion Channel Function
  • Cardiac Electrophysiology

Background:

  • The sinoatrial node (SAN) is the heart's primary pacemaker.
  • Ion channels play critical roles in regulating cardiac electrical activity.
  • The specific contribution of Kv1.1 channels to SAN pacemaking is not fully understood.

Purpose of the Study:

  • To investigate the functional role of Kv1.1 channels in the sinoatrial node.
  • To determine the impact of Kv1.1 channel activity on cardiac pacemaking.

Main Methods:

  • Utilized electrophysiological techniques to study Kv1.1 channel currents.
  • Performed experiments on sinoatrial node cells.
  • Analyzed the effects of Kv1.1 channel modulation on heart rate.

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Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
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Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique

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Measurement of Ion Concentration in the Unstirred Boundary Layer with Open Patch-Clamp Pipette: Implications in Control of Ion Channels by Fluid Flow
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Measurement of Ion Concentration in the Unstirred Boundary Layer with Open Patch-Clamp Pipette: Implications in Control of Ion Channels by Fluid Flow

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Related Experiment Videos

Last Updated: Jun 17, 2025

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques
07:31

Profiling Voltage-gated Potassium Channel mRNA Expression in Nigral Neurons using Single-cell RT-PCR Techniques

Published on: September 27, 2011

15.2K
Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique
08:11

Voltage-Dependent Potassium Current Recording on H9c2 Cardiomyocytes via the Whole-Cell Patch-Clamp Technique

Published on: November 11, 2022

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Measurement of Ion Concentration in the Unstirred Boundary Layer with Open Patch-Clamp Pipette: Implications in Control of Ion Channels by Fluid Flow
05:42

Measurement of Ion Concentration in the Unstirred Boundary Layer with Open Patch-Clamp Pipette: Implications in Control of Ion Channels by Fluid Flow

Published on: January 7, 2019

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Main Results:

  • Kv1.1 channels are expressed at low levels in the sinoatrial node.
  • These channels generate small ionic currents.
  • Despite low expression, Kv1.1 channels significantly influence cardiac pacemaking.

Conclusions:

  • Kv1.1 channels are important regulators of sinoatrial node function.
  • Understanding Kv1.1 channel roles can provide insights into cardiac arrhythmias.
  • Further research into Kv1.1 channel pharmacology may offer therapeutic targets.