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Cerebrospinal Fluid Interleukin-10 Biomarker for Vitreoretinal Lymphoma
Xiao Zhang1, Yan Zhang2, Zhe Zhuang2
1From the Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences (X.Z., C.Z., F.G., R.-P.D., W.-H.Y., Y.-X.C., M.-F.Z.); Key Laboratory of Ocular Fundus Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College (X.Z., C.Z., F.G., R.-P.D., W.-H.Y., Y.-X.C., M.-F.Z.).
Cerebrospinal fluid (CSF) interleukin-10 (IL-10) is a key biomarker for vitreoretinal lymphoma (VRL). Elevated CSF IL-10 levels correlate with intracranial lesions and can help monitor disease progression.
Area of Science:
- Ophthalmology
- Neurology
- Oncology
Background:
- Vitreoretinal lymphoma (VRL) is a rare intraocular malignancy.
- Accurate diagnosis and monitoring of VRL, particularly central nervous system involvement, remain challenging.
- Biomarkers for VRL are crucial for effective management.
Purpose of the Study:
- To investigate the correlation between cerebrospinal fluid (CSF) interleukin-10 (IL-10) levels and clinical characteristics in patients with VRL.
- To assess the utility of CSF IL-10 as a biomarker for VRL, especially for intracranial lesions.
Main Methods:
- Retrospective observational case series of 41 VRL patients.
- Analysis of CSF for biochemical, cytologic, flow cytometry, and cytokine detection (IL-10, IL-6).
- Correlation of CSF IL-10 levels with ocular symptoms, anterior chamber inflammation, retinal lesions, and intracranial lesions.
Main Results:
- CSF IL-10 levels were elevated in 90.2% of VRL patients and higher in those with intracranial lesions.
- CSF IL-10 levels decreased after systemic treatment and rose before intracranial lesion onset or recurrence.
- CSF IL-10 levels correlated with ocular symptom duration but not with aqueous humor IL-10 levels or anterior/retinal lesions.
Conclusions:
- CSF IL-10 is a valuable biomarker in VRL.
- CSF IL-10 is particularly useful for monitoring the development and recurrence of intracranial lesions in VRL patients.
