Related Experiment Video
Updated: Jun 17, 2025
15:43
Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice
Published on: March 17, 2014
22.7K
Associations Between Chronic Rhinosinusitis and the Development of Non-Cystic Fibrosis Bronchiectasis
So Lim Kim1, Brian S Schwartz2, Thanh-Huyen Vu3
1Division of Allergy and Immunology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Ill.
The Journal of Allergy and Clinical Immunology. in Practice
|August 7, 2024
Summary
Chronic rhinosinusitis (CRS) significantly increases the risk of developing non-cystic fibrosis (CF) bronchiectasis. Patients with CRS, particularly those with asthma or COPD, face a higher likelihood of developing this condition.
Area of Science:
- Pulmonology
- Otolaryngology
- Medical Research
Background:
- Chronic rhinosinusitis (CRS) is increasingly recognized for its potential systemic effects.
- Existing research suggests a link between CRS and non-cystic fibrosis (CF) bronchiectasis.
Purpose of the Study:
- To investigate whether a diagnosis of CRS elevates the risk of developing non-CF bronchiectasis.
- To quantify the association between CRS and the incidence of non-CF bronchiectasis.
Main Methods:
- Retrospective analysis of electronic medical records from an academic center (2006-2015).
- Comparison of patients with CRS (with or without asthma/COPD) against a matched control group without CRS, asthma, or COPD.
- Identification of bronchiectasis via chest computed tomography (CT) scan reports.
Main Results:
- Patients with CRS exhibited a significantly higher odds of developing bronchiectasis (OR 1.63) compared to controls.
- The association remained significant in patients with CRS and co-existing asthma or COPD (OR 1.98).
- After adjusting for confounders, the association was attenuated in CRS-only patients but remained significant in CRS with asthma/COPD patients (OR 1.78).
Conclusions:
- Chronic rhinosinusitis is a risk factor for the future development of non-CF bronchiectasis.
- Individuals with CRS, especially those with comorbid asthma or COPD, have an elevated risk of developing bronchiectasis.
More Related Videos
Related Concept Videos
01:23Cystic Fibrosis: Pathogenesis
201
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
201
01:24Cystic Fibrosis: Management
150
Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...
Sinus disease and chronic...
150
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
2.7K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
2.7K
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
2.8K
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
2.8K
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
2.7K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
2.7K
01:20Asthma: Pathogenesis and Management
378
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
378