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Biomimetic nanocomplex based corneal neovascularization theranostics.

Jinfa Ye¹, Yuhang Cheng¹, Xiaofei Wen²

¹Xiamen University Affiliated Xiamen Eye Center, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen 361102, China; Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, Xiamen 361102, China.

Journal of Controlled Release : Official Journal of the Controlled Release Society

|August 7, 2024

Summary

This study presents a novel nanomedicine for treating corneal neovascularization (CNV). Eye drops combining photothermal therapy and chemotherapy offer an effective, safe approach to inhibit blood vessel growth and prevent blindness.

Keywords:

Combined treatment Corneal neovascularization Nanomedicine Photothermal therapy Theranostics

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Published on: August 16, 2014

Area of Science:

Ophthalmology
Nanomedicine
Biomaterials

Background:

Corneal neovascularization (CNV) is a leading cause of blindness globally.
Current treatments for CNV face challenges with repeated administration and poor drug bioavailability.
There is a need for innovative therapeutic strategies to effectively manage CNV.

Purpose of the Study:

To develop and evaluate a novel nanomedicine for treating corneal neovascularization (CNV).
To combine photothermal therapy and chemotherapy for enhanced CNV inhibition.
To improve drug delivery and bioavailability for sustained therapeutic effects.

Main Methods:

SU6668 (receptor tyrosine kinase inhibitor) and indocyanine green (ICG) were loaded into poly(lactic-co-glycolic acid) (PLGA) nanoparticles.
Nanoparticles were coated with anti-VEGFR2 single chain antibody (AbVr2 scFv) engineered cell membrane vesicles.
The nanomedicine was administered via eye drops, with laser irradiation inducing hyperthermia for vessel blockade and drug release.

Main Results:

The nanomedicine effectively blocked blood vessels via laser-induced hyperthermia.
Photothermal effect triggered nanomaterial degradation, releasing SU6668 for sustained anti-neovascularization effects.
SU6668 inhibited heat shock protein 70 (HSP70) expression, enhancing photothermal-induced cell death.

Conclusions:

The combination of photothermal therapy and chemotherapy offers a novel, effective, and safe treatment for CNV.
This nanomedicine approach demonstrates potential for improved drug delivery and sustained therapeutic action.
The study highlights a promising strategy for combating blindness caused by corneal neovascularization.