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Metal-Organic Framework Nanozymes: From Rational Design and Synthesis to Biomedical Applications.

Shundong Cai1,2,3, Mengdie Li1,2, Songyi Wang1,2,3

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Metal-organic framework (MOF) nanozymes show promise for biomedical uses due to their tunable catalytic activity. This review guides their rational design by linking structure to function for enhanced performance.

Keywords:
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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Metal-organic framework (MOF) nanozymes exhibit significant potential in biomedical applications.
  • Their catalytic activity is influenced by metal ions, organic ligands, morphology, and pore size.
  • A systematic understanding linking structural features to functional performance is currently limited.

Purpose of the Study:

  • To systematically analyze how structural features (metal ions, organic ligands, morphology) influence MOF nanozyme catalytic activity.
  • To summarize synthesis methods, highlighting advantages and limitations.
  • To explore biomedical applications and underlying catalytic mechanisms of MOF nanozymes.

Main Methods:

  • Literature review and systematic analysis of existing research on MOF nanozymes.
  • Case studies illustrating biomedical applications and catalytic mechanisms.
  • Critical analysis of challenges and future research directions.

Main Results:

  • The selection of metal ions and organic ligands critically impacts MOF nanozyme catalytic activity.
  • Morphology and pore size optimization further enhance catalytic efficiency.
  • Various synthesis methods offer different advantages and limitations for MOF nanozyme production.

Conclusions:

  • Rational design of MOF nanozymes requires a deep understanding of structure-activity relationships.
  • MOF nanozymes present diverse biomedical applications driven by their catalytic properties.
  • Addressing current challenges is crucial for advancing MOF nanozyme technology.