Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of the Digestive System01:25

Regulation of the Digestive System

479
Digestive activity regulation hinges on three primary components. Activation is prompted by a multitude of mechanical and chemical indicators, primarily detected by receptors within the stomach and intestines' walls. These receptors predominantly respond to factors such as mechanical stretching of the organ walls, changes in pH and osmolarity, and the presence of digesting materials and their by-products.
The effectors in this regulation system are glands and smooth muscles. Activation of...
479
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

2.5K
The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the...
2.5K
Histology of the Small Intestine01:27

Histology of the Small Intestine

617
The small intestine exhibits a unique histological structure that significantly enhances its function in digestion and nutrient absorption. These structures include circular folds, villi, and various specialized cells that collectively facilitate the digestion of food.
The intestinal lining features transverse folds called circular folds, each housing fingerlike projections known as intestinal villi. These villi are covered by a layer of simple columnar epithelium, also referred to as...
617
Hormones Secreted by the Stomach01:25

Hormones Secreted by the Stomach

459
Enteroendocrine cells, accounting for only 1% of stomach epithelial cells, play a significant role in digestion and are classified by their digestive hormone secretions.
Each of these hormones secreted by different enteroendocrine cells plays a unique role in digestion. Here are a few examples:
459
Adult Stem Cells01:33

Adult Stem Cells

28.2K
Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
28.2K
Cells and Secretions of the Pancreas01:16

Cells and Secretions of the Pancreas

2.1K
The pancreas, a vital organ within the abdominal cavity, plays dual roles in the digestive and endocrine systems, collaborating with exocrine and endocrine cells to maintain optimal digestion and blood sugar levels.
Exocrine function is carried out by acinar cells, organized into clusters known as acini. These cells contribute to digestion by releasing substantial quantities of enzyme-rich, alkaline digestive juices.
Concurrently, the dispersed clusters of endocrine cells throughout the...
2.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Guiding Principles: Reporting Elements for Gastrointestinal Organoid Research.

Cellular and molecular gastroenterology and hepatology·2026
Same author

Enteroendocrine Cells Regulate Intestinal Barrier Permeability.

bioRxiv : the preprint server for biology·2025
Same author

Enteroendocrine cells regulate intestinal barrier permeability.

American journal of physiology. Cell physiology·2025
Same author

Deriving Human Intestinal Organoids with Functional Tissue-Resident Macrophages All From Pluripotent Stem Cells.

Cellular and molecular gastroenterology and hepatology·2024
Same author

RFX6 regulates human intestinal patterning and function upstream of PDX1.

Development (Cambridge, England)·2024
Same author

RFX6 regulates human intestinal patterning and function upstream of PDX1.

Development (Cambridge, England)·2024

Related Experiment Video

Updated: Jun 17, 2025

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
07:42

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

68.8K

Enteroendocrine cells regulate intestinal homeostasis and epithelial function.

Jennifer G Nwako1, Heather A McCauley1

  • 1Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill School of Medicine, 111 Mason Farm Road, Molecular Biology Research Building 5341C, Chapel Hill, NC 27599, USA.

Molecular and Cellular Endocrinology
|August 7, 2024
PubMed
Summary

Enteroendocrine cells (EECs) impact gut health by regulating stem cells, nutrient absorption, and barrier function through local signaling. Understanding these paracrine interactions is key to intestinal homeostasis.

Keywords:
Barrier functionEnteroendocrine cellsGastrointestinal diseaseGut hormoneIntestinal homeostasisNutrient absorption

More Related Videos

Organoid-Derived Epithelial Monolayer: A Clinically Relevant In Vitro Model for Intestinal Barrier Function
09:40

Organoid-Derived Epithelial Monolayer: A Clinically Relevant In Vitro Model for Intestinal Barrier Function

Published on: July 29, 2021

6.1K
Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
10:56

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

13.6K

Related Experiment Videos

Last Updated: Jun 17, 2025

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses
07:42

Improved Swiss-rolling Technique for Intestinal Tissue Preparation for Immunohistochemical and Immunofluorescent Analyses

Published on: July 13, 2016

68.8K
Organoid-Derived Epithelial Monolayer: A Clinically Relevant In Vitro Model for Intestinal Barrier Function
09:40

Organoid-Derived Epithelial Monolayer: A Clinically Relevant In Vitro Model for Intestinal Barrier Function

Published on: July 29, 2021

6.1K
Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality
10:56

Combining Human Organoids and Organ-on-a-Chip Technology to Model Intestinal Region-Specific Functionality

Published on: May 5, 2022

13.6K

Area of Science:

  • Gastroenterology and Endocrinology
  • Cell Biology and Physiology
  • Intestinal Homeostasis

Background:

  • Enteroendocrine cells (EECs) are crucial for systemic hormone release, impacting appetite and blood sugar.
  • The local regulatory roles of EEC-derived products within the intestine are less understood.
  • EECs secrete various hormones that influence neighboring intestinal cells.

Purpose of the Study:

  • To investigate the paracrine interactions of EECs with other intestinal cells.
  • To elucidate the role of EECs in regulating intestinal stem cell function and proliferation.
  • To examine EEC influence on nutrient absorption and mucosal barrier integrity.

Main Methods:

  • Review of in vitro and in vivo models for studying EECs.
  • Analysis of EEC-derived signaling pathways.
  • Examination of EEC function in the context of gastrointestinal diseases.

Main Results:

  • EECs modulate intestinal stem cell activity and proliferation.
  • EEC products significantly affect nutrient absorption processes.
  • Paracrine signaling from EECs is vital for maintaining mucosal barrier function.

Conclusions:

  • EECs play a critical role in local intestinal regulation beyond systemic effects.
  • Understanding EEC paracrine signaling is essential for maintaining intestinal homeostasis.
  • Alterations in EECs are implicated in various gastrointestinal disorders.