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Updated: Jun 17, 2025

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
The hematopoietic niche and the autoreactive memory in autoimmune disorders
Matteo Doglio1, Fabio Ciceri2, Chiara Bonini3
1Experimental Hematology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy; Pediatric Immuno-Hematology Unit, IRCCS San Raffaele Hospital, Milan, Italy.
Abstract:
Hematopoiesis is a complex process that takes place inside the bone marrow, where a specialized structure, the bone marrow niche, participates in the maintenance of hematopoietic stem cell functionality. Inflammatory conditions, such as autoimmune diseases, could alter this equilibrium leading to pathologic consequences. Immune cells, which also reside in the bone marrow, directly participate in sustaining the inflammatory state in autoimmune diseases. In particular, memory lymphocytes are key players in the long-term maintenance of the immune response against self-antigens, causing tissue damage and bone marrow alterations.
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