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Updated: Jun 17, 2025

Author Spotlight: Advancements in DNA Nanosensors – Addressing Sensitivity and Selectivity Challenges in Molecular Detection
Published on: February 9, 2024
On the salient limitations of the methods of assembly theory and their classification of molecular biosignatures
Abicumaran Uthamacumaran1,2, Felipe S Abrahão3,4, Narsis A Kiani5,6
1Department of Physics and Psychology (Alumni), Concordia University, Montreal, Canada.
Abstract:
We demonstrate that the assembly pathway method underlying assembly theory (AT) is an encoding scheme widely used by popular statistical compression algorithms. We show that in all cases (synthetic or natural) AT performs similarly to other simple coding schemes and underperforms compared to system-related indexes based upon algorithmic probability that take into account statistical repetitions but also the likelihood of other computable patterns. Our results imply that the assembly index does not offer substantial improvements over existing methods, including traditional statistical ones, and imply that the separation between living and non-living compounds following these methods has been reported before.
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