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Probiotic effect in preterm neonates with sepsis - A systematic review protocol
Faiza Iqbal1, N Siva2, Manasa Kolibylu Raghupathy3
1Department of Paediatrics, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
F1000Research
|August 8, 2024
Summary
This systematic review examines how probiotics can prevent gut dysbiosis in preterm neonates with sepsis. Probiotics help restore healthy gut flora, reducing infections in the Neonatal Intensive Care Unit (NICU).
Area of Science:
- Microbiology
- Neonatal Medicine
- Clinical Pharmacy
Background:
- Neonatal sepsis treatment with antibiotics can disrupt gut microbiota, leading to dysbiosis.
- Probiotics are investigated as agents to restore gut flora balance in preterm infants.
- Reduced nosocomial infections are observed with probiotic use in Neonatal Intensive Care Units (NICUs).
Purpose of the Study:
- To systematically review evidence on probiotics for preventing gut dysbiosis in neonates with sepsis.
- To inform clinical practice and policy regarding probiotic use in neonatal intensive care.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) involving preterm neonates with sepsis.
- Comprehensive literature search across multiple databases (e.g., PubMed, EMBASE, Scopus).
- Data extraction and critical appraisal by two independent reviewers, following PRISMS-P 2020 guidelines.
Main Results:
- This section is to be populated upon completion of the systematic review.
Conclusions:
- Findings will guide evidence-based implementation of probiotics to prevent gut dysbiosis in septic neonates.
- The review aims to support best clinical practices and policy development in neonatal intensive care.
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