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Updated: Jun 17, 2025

A Heterotopic Mouse Model for Studying Laryngeal Transplantation
Published on: January 13, 2023
Total Laryngeal Transplant in the Setting of Active Laryngeal Malignancy
David G Lott1, Girish K Mour2, Danielle N Grandjean3
1Larynx and Trachea Transplantation Program, Mayo Clinic Arizona, Phoenix; Department of Otolaryngology-Head and Neck Surgery, Mayo Clinic Arizona, Phoenix; Center for Regenerative Biotherapeutics, Mayo Clinic Arizona, Phoenix; Head and Neck Regenerative Medicine Laboratory, Mayo Clinic Arizona, Phoenix.
Abstract:
Laryngeal transplant (LT) is a promising option to restore quality of life in patients with severe laryngeal dysfunction or a laryngectomy. These patients may be tracheostomy tube dependent or gastrostomy tube dependent and may lose their ability to verbally communicate. The loss of these important functions frequently results in social isolation and a severe decrease in quality of life. Laryngeal transplant has the potential to restore all of these important laryngeal functions. Herein, we report the first known documented LT performed in the setting of laryngeal chondrosarcoma.
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