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Author Spotlight: Epigenetic Modifications and Metabolic Rewiring as Targets for Cancer Therapy
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Author Spotlight: Epigenetic Modifications and Metabolic Rewiring as Targets for Cancer Therapy

Published on: October 18, 2024

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Transglutaminase 2-mediated histone monoaminylation and its role in cancer

Huapeng Li1,2,3, Jinghua Wu2,3, Nan Zhang2,3

  • 1Molecular, Cellular, and Developmental Biology Graduate Program, The Ohio State University, Columbus, OH 43210, U.S.A.

Bioscience Reports
|August 8, 2024
PubMed

Insights

Transglutaminase 2 (TGM2) modifies histones, creating an epigenetic mark enriched in cancer cells. This review explores TGM2-mediated histone monoaminylation and its therapeutic potential in cancer treatment.

Area of Science:

  • Biochemistry and Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • Transglutaminase 2 (TGM2) is a multifunctional enzyme involved in cancer progression.
  • TGM2 catalyzes various protein post-translational modifications (PTMs), including cross-linking and hydrolysis.
  • Histones are identified as key substrates of TGM2, leading to histone monoaminylation.

Purpose of the Study:

  • To review recent advances in TGM2-mediated histone monoaminylation.
  • To elucidate the role of TGM2-mediated histone monoaminylation in cancer.
  • To discuss methodologies for studying this epigenetic mark and TGM2's therapeutic potential.

Main Methods:

  • Literature review of recent scientific publications.
  • Analysis of TGM2's enzymatic activities and substrate interactions.
  • Discussion of research methodologies for epigenetic mark investigation.

Main Results:

  • Histone monoaminylation by TGM2 is an emerging epigenetic mark.
  • This mark is highly enriched in cancer cells.
  • Histone monoaminylation significantly regulates gene transcription.

Conclusions:

  • TGM2-mediated histone monoaminylation plays a crucial role in cancer.
  • Understanding this epigenetic mark offers insights into cancer biology.
  • TGM2 represents a potential druggable target for cancer therapy.
Keywords:
cancer biologyepigeneticsgene transcriptionhistone monoaminylationtransglutaminase 2 (TGM2)

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