Related Experiment Video
Updated: Jun 17, 2025
10:25
In Utero Intra-cardiac Tomato-lectin Injections on Mouse Embryos to Gauge Renal Blood Flow
Published on: February 4, 2015
9.7K
Origins and Molecular Mechanisms Underlying Renal Vascular Development.
Yusuke Nishimura1, Sanshiro Hanada
1Department of Clinical Engineering, Faculty of Medical Science and Technology, Gunma Paz University, Takasaki, Japan.
Kidney360
|August 8, 2024
Summary
Understanding kidney vascular development is key for homeostasis. This review details how blood vessels form and align with nephrons, crucial for kidney function and disease therapies.
Area of Science:
- Nephrology
- Vascular Biology
- Developmental Biology
Background:
- Kidney homeostasis relies on intricate vascular structures.
- Proper kidney function requires spatial alignment between nephrons and blood vessels.
- Renal vascularization is essential for filtration, electrolyte balance, blood pressure, and hormone production.
Purpose of the Study:
- To summarize current knowledge on renal vascular development.
- To elucidate the origin, formation, and key molecular players in kidney vasculature.
- To identify cellular and molecular mechanisms governing renal vascular development.
Main Methods:
- Comprehensive literature review of existing studies.
- Analysis of cellular and molecular mechanisms.
- Synthesis of current understanding of renal vascular development.
Main Results:
- Specific molecules are critical for renal vascular development.
- These molecules ensure proper spatial alignment between nephrons and blood vessels.
- Elucidation of mechanisms governing the formation of kidney vasculature.
Conclusions:
- Understanding renal vascular development is vital for advancing kidney regenerative medicine.
- This knowledge offers potential therapeutic targets for kidney diseases.
- Further research into these mechanisms can improve treatments for renal pathologies.
Related Concept Videos
01:10Mechanism of Angiogenesis
5.4K
Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...
5.4K
01:24Regulation of Angiogenesis and Blood Supply
2.5K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.5K
01:07Development of Blood Vessels
553
The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
553
01:20Overview of the Vascular System
2.7K
The vascular system comprises an extensive network of arteries, capillaries, and veins. The vascular system can be broadly divided into the blood and lymphatic systems. Typically, blood vessels can be categorized into three histological regions: tunica intima, tunica media, and tunica adventitia. The tunica intima consists of a single layer of endothelial cells attached to the basal lamina. Underlying the basal lamina is a connective tissue layer and an elastic lamina that gives stability and...
2.7K
01:10Nephrons
2.3K
The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma...
2.3K
01:20Renal Corpuscle
1.8K
The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.8K