Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The fetal neural tube: is intervention progress?

M Michejda

    Zeitschrift Fur Kinderchirurgie : Organ Der Deutschen, Der Schweizerischen Und Der Osterreichischen Gesellschaft Fur Kinderchirurgie = Surgery in Infancy and Childhood
    |December 1, 1985
    PubMed
    Summary

    Fetal therapy advances include a new shunt for hydrocephalus and an allogeneic bone paste for spina bifida repair. Further research is needed to understand fetal brain regeneration for improved in utero treatments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Source of cell injected is a critical factors for short and long engraftment in xeno-transplantation.

    Cell proliferation·2008
    Same author

    Analysis and characterization of hematopoietic progenitor cells from fetal bone marrow, adult bone marrow, peripheral blood, and cord blood.

    Pediatric research·1999
    Same author

    Evaluation of early second trimester maternal serum creatine kinase isoenzyme BB as a marker of poor pregnancy outcome.

    Fetal diagnosis and therapy·1998
    Same author

    Comparative study of hemopoietic precursors from fetal and adult bone marrow: utilization of stem cells derived from miscarriages.

    Fetal diagnosis and therapy·1996
    Same author

    Quo vadis? Fetal tissue transplantation.

    Journal of hematotherapy·1996
    Same author

    Suitability of fetal tissue for transplantation.

    JAMA·1995

    Area of Science:

    • Reproductive Medicine
    • Developmental Biology
    • Neurosurgery

    Background:

    • Fetal therapy is an emerging field with specialized centers worldwide.
    • In utero treatment of fetal hydrocephalus faces challenges in patient selection, shunt design, and understanding pathogenesis.
    • The fetal brain exhibits significant regenerative capacity, though poorly understood.

    Purpose of the Study:

    • To develop and prepare for clinical trials a novel ventriculo-amniotic shunt for fetal hydrocephalus.
    • To investigate the potential of allogeneic bone paste for in utero repair of skull defects and spina bifida.

    Main Methods:

    • Development of a ventriculo-amniotic shunt with a one-way valve for continuous cerebrospinal fluid (CSF) evacuation.
    • Application of an allogeneic bone paste, moldable for bone defect restoration, in animal models with surgically induced spina bifida-like lesions.

    Related Experiment Videos

    Main Results:

    • A novel shunt model for fetal hydrocephalus is nearing readiness for clinical trials.
    • Allogeneic bone paste demonstrated efficacy in repairing skull defects and spina bifida-like lesions in utero in animal models.

    Conclusions:

    • The developed shunt offers a potential solution for in utero hydrocephalus management.
    • Allogeneic bone paste presents a promising biomaterial for fetal surgical repair of bone defects and neural tube defects like spina bifida.