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Ubiquitin: A double-edged sword in hepatitis B virus-induced hepatocellular carcinoma

Arpita Kar1, Sandipan Mukherjee1, Soumyadeep Mukherjee2

  • 1Department of Signal Transduction & Biogenic Amines, Chittaranjan National Cancer Institute, Kolkata, India.

Virology
|August 8, 2024
PubMed

Insights

Ubiquitination plays a dual role in Hepatitis B virus (HBV) infection, influencing both viral progression and host cell transformation. Understanding these ubiquitination events is key to developing new treatments for HBV-induced liver cancer.

Area of Science:

  • Virology
  • Molecular Biology
  • Cancer Research

Background:

  • Hepatitis B virus (HBV) is a major cause of liver cancer and mortality worldwide.
  • Despite existing therapies and vaccines, the precise mechanisms of HBV pathogenesis remain incompletely understood.
  • Novel strategies targeting virus-host interactions are needed to combat HBV-related diseases.

Purpose of the Study:

  • To review the current literature on ubiquitination's role in the Hepatitis B virus (HBV) host-pathogen interactome.
  • To elucidate how ubiquitination events influence HBV infection, replication, and the development of hepatocellular carcinoma (HCC).
  • To highlight potential therapeutic targets for novel anti-HBV and anti-cancer strategies.

Main Methods:

  • Comprehensive literature review of studies investigating ubiquitination in HBV infection and hepatocellular carcinoma.
  • Analysis of research detailing the ubiquitination of both viral and host proteins.
  • Synthesis of findings on the dual role of ubiquitination in restricting or promoting HBV pathogenesis.

Main Results:

  • Ubiquitination significantly impacts the turnover and function of viral and host proteins during HBV infection.
  • Certain ubiquitination events restrict HBV replication and carcinogenesis, while others promote hepatocarcinoma development.
  • The interplay between HBV and host ubiquitination machinery is crucial for viral persistence and oncogenesis.

Conclusions:

  • Ubiquitination is a critical post-translational modification modulating the host-HBV crosstalk.
  • Targeting specific ubiquitination pathways offers potential for developing new therapeutic interventions against HBV-induced liver cancer.
  • Further research into ubiquitination dynamics can lead to novel strategies for controlling HBV-related hepato-carcinogenesis globally.
Keywords:
DegradationHepatitis B virusHepatocellular carcinomaProteasomeUbiquitinUbiquitination

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