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Sex differences in pediatric sepsis-a systematic review protocol

Uchenna Kennedy1, Juliette Moulin2, Luregn J Schlapbach3,4

  • 1Children's Research Center, University Children's Hospital Zurich, Steinwiesstrasse 75, 8032, Zurich, Switzerland. uchenna.kennedy@kispi.uzh.ch.

Systematic Reviews
|August 8, 2024
PubMed

Insights

This systematic review investigates sex differences in pediatric sepsis outcomes. Understanding these differences is crucial for improving survival rates in children affected by sepsis.

Area of Science:

  • Pediatric critical care medicine
  • Immunology
  • Epidemiology

Background:

  • Pediatric sepsis is a major global cause of child mortality, responsible for over 3 million deaths annually.
  • Sex and gender significantly influence disease outcomes, with adult studies suggesting potential protective effects of estrogens in septic shock.
  • Existing research highlights sex-specific immunological differences in pediatric populations, yet the impact on sepsis outcomes remains unexamined.

Purpose of the Study:

  • To systematically evaluate the association between sex and survival outcomes in pediatric sepsis.
  • To identify potential sex-specific differences in treatment responses and disease progression in children with sepsis.

Main Methods:

  • A systematic literature search of MEDLINE and Embase databases will be conducted.
  • Inclusion criteria comprise English language randomized trials and cohort studies involving children aged 37 weeks gestational age to 18 years with sepsis, severe sepsis, or septic shock.
  • Primary outcome is hospital mortality; secondary outcomes include pediatric intensive care unit and hospital length of stay.

Main Results:

  • This section is to be populated upon study completion.

Conclusions:

  • Expected results will illuminate the relationship between sex and pediatric sepsis outcomes.
  • Findings may guide future research into pathophysiological and socioeconomic factors contributing to observed sex differences in clinical outcomes.
Abstract

Keywords:
ChildhoodPediatricSepsisSeptic shockSex and gender

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