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Association between bronchial asthma and TSLP gene polymorphism: a systematic review and meta-analysis
Abhigan B Shrestha1, Pashupati Pokharel2, Harendra Singh3
1Department of Internal Medicine, M Abdur Rahim Medical College, Dinajpur, Bangladesh.
Annals of Medicine and Surgery (2012)
|August 9, 2024
Summary
This meta-analysis found that thymic stromal lymphopoietin (TSLP) gene single nucleotide polymorphism (SNP) rs2289278 is protective against asthma, while SNP rs3806933 increases asthma risk. These findings support anti-TSLP therapies.
Area of Science:
- Genetics
- Immunology
- Respiratory Medicine
Background:
- Asthma is a chronic respiratory disease influenced by genetic factors.
- Thymic stromal lymphopoietin (TSLP) plays a crucial role in allergic airway inflammation.
Purpose of the Study:
- To investigate the association between common single nucleotide polymorphisms (SNPs) in the TSLP gene and bronchial asthma.
- To evaluate the potential of TSLP gene variants as biomarkers for asthma risk.
Main Methods:
- A systematic literature search was conducted across PubMed, Embase, Web of Science, and Google Scholar.
- Meta-analysis of 11 studies involving 3121 asthma cases and 3041 controls.
- Odds ratios (OR) with 95% confidence intervals (CI) were calculated to assess the association in dominant and recessive inheritance models.
Main Results:
- SNP rs2289278 demonstrated a protective effect against asthma development (OR=0.65, P=0.04).
- SNP rs3806933 was associated with an increased risk of asthma (OR=1.32, P<0.01).
- SNPs rs2289276 and rs1837253 showed no significant association overall, but rs1837253 was protective in Asian populations, and rs2289276 indicated risk in Asian adults.
Conclusions:
- The TSLP gene SNPs rs2289278 and rs3806933 are significantly associated with asthma risk and protection, respectively.
- These genetic findings provide a basis for understanding TSLP's role in asthma pathogenesis.
- The study supports the therapeutic targeting of TSLP, as exemplified by tezepelumab.
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