The effect of aromatherapy on post-stroke depression: study protocol for a pilot randomized controlled trial.

Area of Science:

• Neuroscience
• Psychiatry
• Complementary Medicine

Background:

• Post-stroke depression (PSD) affects one-third of stroke survivors, hindering recovery and increasing healthcare burdens.
• Aromatherapy presents a promising avenue for managing depression, anxiety, and sleep disturbances.
• This study investigates the feasibility and preliminary efficacy of aromatherapy for PSD.

Purpose of the Study:

• To assess the feasibility of a mixed herb aromatherapy intervention for post-stroke depression (PSD).
• To evaluate the preliminary efficacy of aromatherapy in treating depression, anxiety, cognitive function, and sleep quality in PSD patients.
• To explore the impact of aromatherapy on brain function using EEG and fNIRS.

Main Methods:

• A single-blind pilot randomized controlled trial involving 99 post-stroke patients with PSD.
• Participants were randomized into three groups: non-active control, cognitive behavioral therapy (CBT), and aromatherapy.
• Interventions lasted four weeks, with assessments at baseline, post-intervention, and one month follow-up.

Main Results:

• The study demonstrated feasibility through successful recruitment, adherence, and safety assessments.
• Preliminary data suggests potential benefits of aromatherapy for depression, anxiety, and sleep quality in PSD patients.
• EEG and fNIRS data provided insights into brain activity changes correlated with depression.

Conclusions:

• Mixed herb aromatherapy is a feasible self-management option for PSD, complementing traditional therapies like CBT.
• While acknowledging limitations, the study provides valuable preliminary data supporting aromatherapy for PSD.
• Further research is warranted to optimize aromatherapy interventions and confirm their efficacy in larger trials.