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Updated: Jun 17, 2025

Preparation of Carbon Nanosheets at Room Temperature
Published on: March 8, 2016
2-Chloro-3-cyano-4-nitrobenzyl pyridinium bromide as a potent anti-lung cancer molecule prepared using a single-step
Sadaiyan Govindaraj1, Kilivelu Ganesan1, Perumal Elumalai2
1PG& Research Department of Chemistry, Presidency College Chennai 600005 India kiliveluganesan@yahoo.co.in.
Abstract:
Mono-/dimeric-substituted pyridinium and pyrazolium bromides were prepared under conventional and solvent-free silica-supported domestic microwave conditions. The atom economy, environmental product mass intensity and product mass intensity for solvent-free reactions showed significant importance for the synthesis of target molecules. 4-Nitrobenzyl-substituted pyridinium bromide showed potent anticancer properties compared with mono-/dimeric-substituted pyridinium and pyrazolium bromides against a lung cancer cell line (A-549). Molecular simulation studies were carried out for mono-/dimeric-substituted pyridinium and pyrazolium bromide against protein human CDK1/cyclinB1/CKS2 using the AutoDock program.
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