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Updated: Jun 17, 2025
11:39
The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
Published on: July 11, 2013
38.9K
Management of Pustular Psoriasis; The Way Ahead.
Shrichand G Parasramani1, Bikash R Kar2, Sushil Tahiliani3
1From the Department of DVL, Lilavati Hospital, Mumbai, Maharashtra, India.
Indian Journal of Dermatology
|August 9, 2024
Summary
Pustular psoriasis, a severe skin condition, is now understood to involve interleukin-36 (IL-36). Biologics targeting IL-36 offer a successful new treatment approach for this potentially life-threatening disease.
Area of Science:
- Dermatology
- Immunology
- Pathogenesis of Skin Diseases
Background:
- Pustular psoriasis is a severe, potentially life-threatening variant of psoriasis.
- Traditional treatments like corticosteroids, acitretin, cyclosporine, and methotrexate have shown unpredictable efficacy.
- Recent research links the pathogenesis of pustular psoriasis to interleukin-36 (IL-36).
Purpose of the Study:
- To review the latest understanding of pustular psoriasis pathogenesis.
- To discuss current and emerging management strategies for pustular psoriasis.
Main Methods:
- This is a narrative review.
- Literature search on pustular psoriasis, IL-36, and treatment modalities.
Main Results:
- Interleukin-36 (IL-36) plays a key role in the pathogenesis of pustular psoriasis.
- Biologics targeting IL-36 receptors have demonstrated significant success in managing the condition.
- Conventional systemic therapies offer limited and unpredictable outcomes.
Conclusions:
- Targeting the IL-36 pathway represents a significant advancement in pustular psoriasis management.
- Biologic therapies offer a highly effective treatment option for pustular psoriasis.
- Further research into IL-36's role may lead to improved therapeutic strategies.
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