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Updated: Jun 17, 2025
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Measuring G-protein-coupled Receptor Signaling via Radio-labeled GTP Binding
Published on: June 9, 2017
16.3K
G protein-coupled receptor (GPCR) pharmacogenomics
Miles D Thompson1, David Reiner-Link2, Alessandro Berghella2
1Krembil Brain Institute, Toronto Western Hospital, Toronto, Ontario, Canada.
Critical Reviews in Clinical Laboratory Sciences
|August 9, 2024
Summary
Pharmacogenomics, using next-generation sequencing, now encompasses pharmacogenetics by identifying genetic variants affecting drug responses. G protein-coupled receptor (GPCR) variants significantly impact drug efficacy and safety, guiding personalized medicine.
Area of Science:
- Genomics and Bioinformatics
- Pharmacology and Therapeutics
Background:
- Pharmacogenetics investigates genetic variations influencing drug responses.
- Pharmacogenomics employs a genome-wide approach, enhanced by next-generation sequencing (NGS).
- G protein-coupled receptors (GPCRs) are crucial drug targets, making their genetic variants highly relevant.
Purpose of the Study:
- To explore the impact of G protein-coupled receptor (GPCR) genetic variants on drug response.
- To highlight the integration of pharmacogenetics into pharmacogenomics through advanced sequencing technologies.
- To discuss the clinical implications of GPCR pharmacogenomic data for personalized medicine.
Main Methods:
- Utilizing next-generation sequencing (NGS) for genome-wide variant identification.
- Analyzing functional studies of G protein-coupled receptor (GPCR) variants.
- Integrating computational tools and publicly available genomic data.
Main Results:
- GPCR variants (coding, non-coding, indels) affect receptor function, cell surface expression, and ligand binding.
- Pharmacogenomic data reveals associations between GPCR variants and drug response phenotypes.
- Examples include roles in COVID-19, cytokine storms, and protease-activated receptor interventions.
Conclusions:
- GPCR pharmacogenomics is essential for understanding drug response and adverse reactions.
- Increased data on GPCR variants will lead to improved drug labeling and clinical guidance.
- Personalized drug selection based on GPCR pharmacogenomic profiles offers significant patient benefits.
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