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Visualization and Quantification of Brown and Beige Adipose Tissues in Mice using [18F]FDG Micro-PET/MR Imaging
Published on: July 1, 2021
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Hyaluronan Mediates Cold-Induced Adipose Tissue Beiging.
Xi Chen1, Yifan Wang2, Huiqiao Li1
1USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Cells
|August 9, 2024
Summary
Cold exposure enhances adipose tissue beiging by increasing hyaluronic acid (HA) levels. This suggests HA could be a novel therapeutic target for obesity and metabolic diseases, unlike beta-3 adrenergic receptor agonists.
Area of Science:
- Metabolic research
- Adipose tissue biology
- Extracellular matrix dynamics
Background:
- Adipose tissue beiging, the emergence of beige adipocytes in white adipose tissue, improves metabolism.
- Beige adipocytes dissipate energy and secrete adipokines, beneficial for obesity and metabolic diseases.
- Cold exposure and beta-3 adrenergic receptor (AR) agonists stimulate beige adipocyte formation via distinct mechanisms.
Purpose of the Study:
- Investigate the role of extracellular matrix (ECM) components, specifically hyaluronic acid (HA), in cold-induced adipose tissue beiging.
- Compare the effects of cold exposure versus beta-3 AR agonist on HA levels in adipose tissue.
- Determine if modulating HA levels impacts adipose tissue beiging.
Main Methods:
- Transcriptional analysis of inguinal white adipose tissue (iWAT) following cold exposure.
- Measurement of HA levels in iWAT after cold exposure and beta-3 AR agonist (CL316,243) treatment.
- Genetic manipulation of HA levels in iWAT using Has2 (to increase HA) and Spam1 (to decrease HA) overexpression in mice.
Main Results:
- Cold exposure specifically increased iWAT HA levels, while CL316,243 did not.
- Overexpression of Has2 enhanced cold-induced adipose tissue beiging.
- Overexpression of Spam1 reduced cold-induced adipose tissue beiging, confirming HA's role.
Conclusions:
- Hyaluronic acid (HA) plays a crucial role in promoting adipose tissue beiging, a process specific to cold exposure.
- Modulating HA levels offers a potential new therapeutic strategy for metabolic diseases.
- Targeting HA may overcome the limitations of beta-3 AR agonists in clinical applications for obesity.
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