Related Experiment Video
Updated: Jun 17, 2025
07:36
Tumor Transplantation for Assessing the Dynamics of Tumor-Infiltrating CD8+ T Cells in Mice
Published on: June 12, 2021
6.5K
CD137 (4-1BB) and T-Lymphocyte Exhaustion
Paula Molero-Glez1, Arantza Azpilikueta1, Laura Mosteo1
1Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.
Summary
CD137 (4-1BB) costimulation powerfully activates T cells against tumors, enhancing anti-PD(L)1 therapies. This approach may prevent and reverse T-cell exhaustion, improving cancer immunity.
Area of Science:
- Immunology
- Oncology
- T-cell biology
Background:
- CD137 (4-1BB) is a costimulatory receptor on immune cells.
- T-cell exhaustion limits antitumor immune responses.
- Checkpoint inhibitors like anti-PD(L)1 are crucial in cancer immunotherapy.
Purpose of the Study:
- To investigate the role of CD137 (4-1BB) costimulation in enhancing antitumor T-cell responses.
- To explore the synergy between CD137 (4-1BB) and anti-PD(L)1 therapies.
- To determine if CD137 (4-1BB) ligation can prevent or reverse T-cell exhaustion.
Main Methods:
- Utilizing bispecific constructs for combined CD137 (4-1BB) and anti-PD(L)1 targeting.
- Assessing T-cell activation and proliferation in antitumor contexts.
- Evaluating T-cell exhaustion markers and functionality.
Main Results:
- CD137 (4-1BB) costimulation potently activated antitumor T lymphocytes.
- Combined therapy showed synergistic antitumor efficacy, particularly with bispecific constructs.
- Evidence suggests 4-1BB ligation prevents and may revert T-cell exhaustion.
Conclusions:
- CD137 (4-1BB) costimulation is a promising strategy to enhance T-cell-mediated antitumor immunity.
- The combination of CD137 (4-1BB) and anti-PD(L)1 checkpoint inhibitors offers synergistic benefits.
- Targeting 4-1BB may overcome T-cell exhaustion, a key challenge in cancer immunotherapy.
Related Concept Videos
01:22T Cell Activation and Clonal Selection
693
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
693
01:24T Cell Types and Functions
966
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
966
01:27Cytotoxic T Cells-mediated Immune Response
861
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
861