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Glomerular lesions in malignancies.

L Morel-Maroger Striker, G E Striker

    Contributions to Nephrology
    |January 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Malignant diseases can cause kidney glomerular lesions, most commonly minimal lesion nephrotic syndrome in lymphomas and membranous glomerulonephritis in carcinomas. Amyloidosis is now rare, while proliferative glomerulonephritis is seen in chronic lymphocytic leukemia.

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    Area of Science:

    • Nephrology
    • Oncology
    • Pathology

    Background:

    • Glomerular lesions are observed in various malignant diseases, though their incidence is typically low (<2%).
    • The types of glomerular lesions vary significantly depending on the specific malignancy.
    • Amyloidosis, once common, is now infrequent, while other lesions have emerged or become more prevalent.

    Purpose of the Study:

    • To review and summarize the spectrum of glomerular lesions associated with different types of cancer.
    • To highlight the varying incidence and specific types of kidney involvement in malignancies.
    • To explore potential pathogenetic mechanisms linking cancer to glomerular damage.

    Main Methods:

    • Review of existing literature and case series on glomerular pathology in malignant diseases.

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  • Analysis of the frequency and types of glomerular lesions reported in patients with lymphomas, leukemias, and carcinomas.
  • Correlation of specific glomerular findings with underlying cancer types.

    • Main Results:

    • Minimal lesion nephrotic syndrome is the most common glomerular lesion in Hodgkin's disease and other lymphomas.
    • Chronic lymphocytic leukemia is associated with a high proportion of proliferative glomerulonephritis.
    • Membranous glomerulonephritis is the predominant glomerular lesion in carcinomas, often linked to tumor antigens or altered glomerular antigens.
    • Amyloid AA remains a complication in carcinomas, affecting up to 3% of renal adenocarcinomas.

    Conclusions:

    • Glomerular lesions are diverse manifestations of systemic malignancy.
    • The specific type of glomerular lesion often correlates with the type of cancer.
    • Understanding these associations aids in diagnosing and managing kidney complications in cancer patients.