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Related Experiment Video

Updated: Jun 17, 2025

Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
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Rapid Assay Diagnostic for Acute Stroke Recognition (RADAR): study protocol for a diagnostic accuracy study.

Lisa Shaw1, David Burgess2, Anand Dixit3

  • 1Stroke Research Group, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK lisa.shaw@newcastle.ac.uk.

BMJ Open
|August 9, 2024
PubMed
Summary
This summary is machine-generated.

A new portable test accurately identifies large-vessel occlusion (LVO) stroke, potentially speeding up treatment. This diagnostic tool could help select patients for direct transfer to specialized thrombectomy centers, reducing critical delays.

Keywords:
Research DesignSTROKE MEDICINETriage

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Area of Science:

  • Neurology
  • Medical Diagnostics
  • Biomarkers

Background:

  • Large-vessel occlusion (LVO) stroke requires time-critical thrombectomy, often necessitating patient transfer to specialized centers.
  • Current transfer protocols can lead to significant delays in treatment initiation.
  • Accurate and rapid diagnostic tools are needed to streamline patient selection and transfer.

Purpose of the Study:

  • To evaluate the diagnostic accuracy of a novel rapid portable test for identifying LVO stroke.
  • To assess the potential of the test in selecting patients for direct admission to thrombectomy-capable centers.

Main Methods:

  • Prospective observational cohort study (RADAR) in English stroke units.
  • Index test: 'LVOne test' using fingerprick blood to detect d-dimer and glial fibrillary acidic protein.
  • Reference standard: Adjudicated CT/MRI brain±CT/MR angiography to confirm stroke type and LVO.

Main Results:

  • The study aims to determine sensitivity, specificity, and predictive values for LVO stroke detection.
  • A primary analysis population of 276 participants is powered to detect a test specificity of 92% for LVO stroke.
  • A total study population of 552 participants will allow evaluation in milder symptoms and unknown onset times.

Conclusions:

  • The 'LVOne test' shows promise as a rapid, portable diagnostic tool for LVO stroke.
  • Successful implementation could optimize patient pathways and reduce treatment delays.
  • Further validation in broader populations will confirm its clinical utility.